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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MCM2 All Species: 45.76
Human Site: S644 Identified Species: 67.11
UniProt: P49736 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49736 NP_004517.2 904 101896 S644 Y D P S L T F S E N V D L T E
Chimpanzee Pan troglodytes XP_001136482 895 100908 S635 Y D P S L T F S E N V D L T E
Rhesus Macaque Macaca mulatta XP_001099580 870 97929 T618 I S K A G I V T S L Q A R C T
Dog Lupus familis XP_541736 1001 113024 S742 Y D P S L T F S D N V D L T E
Cat Felis silvestris
Mouse Mus musculus P97310 904 102059 S644 Y D P S L T F S E N V D L T E
Rat Rattus norvegicus NP_001101343 905 102125 S645 Y D P S L T F S E N V D L T E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518428 911 102482 S651 Y D P S L T F S E N V D L T E
Chicken Gallus gallus NP_001006139 888 100332 L631 Y D P S L T F L E N V D L T E
Frog Xenopus laevis P55861 886 100243 S629 Y D P S L T F S E N V D L T E
Zebra Danio Brachydanio rerio NP_775364 880 98286 S623 Y D P S L T F S E N V D L T E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49735 887 100396 S629 Y D P S M T F S E N V N L S E
Honey Bee Apis mellifera XP_395109 1005 114136 S748 Y D A S M T F S E N V D L S E
Nematode Worm Caenorhab. elegans Q21902 759 84917 L526 V K D T H D V L K D A T L A K
Sea Urchin Strong. purpuratus XP_001177558 884 100012 S629 Y N P S L T F S E N V D L T E
Poplar Tree Populus trichocarpa
Maize Zea mays Q43704 768 85163 R535 A I F V K Y D R M L H G Q D R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P29469 868 98761 I631 M E Q Q S I S I S K A G I V T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99 95.8 87.4 N.A. 95.5 96 N.A. 93.1 88.2 86.7 80.1 N.A. 63.9 58.4 26.7 73.4
Protein Similarity: 100 99 96.1 89.1 N.A. 97.7 98.3 N.A. 95.7 93.8 93 87.6 N.A. 79.3 73.5 43.2 86.5
P-Site Identity: 100 100 0 93.3 N.A. 100 100 N.A. 100 93.3 100 100 N.A. 80 80 6.6 93.3
P-Site Similarity: 100 100 13.3 100 N.A. 100 100 N.A. 100 93.3 100 100 N.A. 100 93.3 33.3 100
Percent
Protein Identity: N.A. 30.3 N.A. N.A. 41.9 N.A.
Protein Similarity: N.A. 48.8 N.A. N.A. 58.9 N.A.
P-Site Identity: N.A. 0 N.A. N.A. 0 N.A.
P-Site Similarity: N.A. 0 N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 7 7 0 0 0 0 0 0 13 7 0 7 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % C
% Asp: 0 69 7 0 0 7 7 0 7 7 0 69 0 7 0 % D
% Glu: 0 7 0 0 0 0 0 0 69 0 0 0 0 0 75 % E
% Phe: 0 0 7 0 0 0 75 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 7 0 0 0 0 0 0 13 0 0 0 % G
% His: 0 0 0 0 7 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 7 7 0 0 0 13 0 7 0 0 0 0 7 0 0 % I
% Lys: 0 7 7 0 7 0 0 0 7 7 0 0 0 0 7 % K
% Leu: 0 0 0 0 63 0 0 13 0 13 0 0 82 0 0 % L
% Met: 7 0 0 0 13 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 0 0 75 0 7 0 0 0 % N
% Pro: 0 0 69 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 7 7 0 0 0 0 0 0 7 0 7 0 0 % Q
% Arg: 0 0 0 0 0 0 0 7 0 0 0 0 7 0 7 % R
% Ser: 0 7 0 75 7 0 7 69 13 0 0 0 0 13 0 % S
% Thr: 0 0 0 7 0 75 0 7 0 0 0 7 0 63 13 % T
% Val: 7 0 0 7 0 0 13 0 0 0 75 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 75 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _